Items tagged with HIV coinfection
Ukraine: Concurrent treatment for HIV/TB co-infection breaks up “deadly alliance” (post)
In a continuation of World TB Day coverage, the following guest post from study authors Martha Priedeman Skiles and Stephanie Mullen tells how current data from Ukraine show promise for patients co-infected with TB and HIV.
Tuberculosis-associated immune reconstitution inflammatory syndrome: a manifestation of adaptive or innate immunity? (post)
In The Lancet Infectious Diseases, Shruthi Ravimohan and colleagues1 investigate whether immunological profiles before and after antiretroviral therapy (ART) can distinguish patients co-infected with HIV and tuberculosis who develop tuberculosis-associated immune reconstitution inflammatory syndrome (IRIS) from those who do not develop this disorder and those who have early mortality. The investigators noted decreased pre-ART concentrations of several pro-inflammatory cytokines in patients with tuberculosis-associated IRIS (eg, interleukin [IL]-6 adjusted odds ratio [OR] per 1 log10 increase 0·40 [95% CI 0·18–0·89]), which resurged during the disease. After ART initiation, the most prominent changes in patients with tuberculosis-associated IRIS were reported for cytokines related to innate immunity (eg, IL-6: adjusted OR 1·7 [95% CI 1·2–2·5] and tumour necrosis factor [TNFα: 1·5 [1·0–2·2]), whereas recovery of the CD4 T-cell compartment was similar to that shown in control participants who survived without a diagnosis of tuberculosis-associated IRIS.
Uganda and Global Fund sign new grants (post)
KAMPALA, Uganda – Uganda and the Global Fund today signaled a new phase of partnership by signing five new grants for US$226 million to fight HIV and tuberculosis as well as to build resilient and sustainable systems for health in the country.
Early HIV treatment improves survival in some patients with newly diagnosed TB (post)
PITTSBURGH, July 9, 2015 - Starting anti-HIV treatment within two weeks of the diagnosis of tuberculosis, or TB, improved survival among patients with both infections who had very low immune-cell counts, according to an analysis by researchers at the University of Pittsburgh Graduate School of Health. Those with strong immune systems, however, might benefit from waiting until after the end of the six-month TB treatment before initiating anti-HIV therapy, they found.
IAS 2015: Tuberculosis and poor implementation of proven interventions threaten people with HIV and TB (post)
VANCOUVER, Canada – Isoniazid preventive therapy is as effective in staving off tuberculosis as preemptively treating patients with HIV for tuberculosis, research results released here this morning (July 20) showed. The findings came in one of a series of presentations this morning highlighting challenges posed by tuberculosis to the lives and well-being of people living with HIV, and failures to use proven interventions.
Presumptive treatment of TB in advanced HIV no better than giving ART and isoniazid (post)
Giving treatment for tuberculosis to all people with very advanced HIV disease at the time they start antiretroviral therapy, before a laboratory diagnosis of TB – so-called empiric treatment – does not reduce the risk of death compared to giving antiretroviral therapy and isoniazid preventive therapy. These findings were presented by Dr Mina Hosseinipour at the Eighth International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015) on Monday.
South Africa submits $380-million concept note for HIV/TB (post)
South Africa on 15 July submitted a joint HIV/TB concept note for some $380.5 million in funding, more than half of which is to support prevention interventions specifically targeting key populations including young women and girls, men who have sex with men and people living in disease hot spots. Of this, $142.2 million constitutes an above-allocation request.
Brown University to help Ghana build HIV, TB research capacity (post)
With $1.45 million over five years from the Fogarty International Center of the National Institutes of Health, a pair of Brown University professors will work with colleagues in Ghana to build the research capacity needed to address the deadly co-epidemics of HIV and tuberculosis.
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