Healio

Mobile clinic screening program identified latent TB in high-risk people

Including tuberculin skin test screening as part of a mobile medical clinic identified a number of patients with latent tuberculosis infection among foreign-born individuals with a high risk of infection, according to data from a recent study.

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Acquired resistance to second-line drugs increased mortality in TB

Patients with tuberculosis who acquire resistance to second-line drugs were more likely to die than those without resistance, according to CDC researchers.

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Shorter time to TB culture detection related to high transmission risk

A time-to-detection of tuberculosis of fewer than 9 days in culture was associated with an increased risk for transmission of the disease, according to researchers from the Heartlands Hospital in Birmingham, England.

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Investigational combination shows activity comparable to standard TB treatment

BOSTON — A combination treatment consisting of bedaquiline, pyrazinamide and PA-824 demonstrated early bactericidal activity against tuberculosis and will be studied in future, longer duration trials, researchers reported here at the 2014 Conference on Retroviruses and Opportunistic Infections.

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Xpert test failed to affect mortality in TB

BOSTON — Replacing smear microscopy with the Xpert MTB/RIF test did not decrease mortality among people with suspected tuberculosis in South Africa, according to study results presented at the 2014 Conference on Retroviruses and Opportunistic Infections.

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Rifapentine, moxifloxacin active as part of shorter TB regimen

BOSTON — A shorter treatment regimen consisting of rifapentine, moxifloxacin, isoniazid and pyrazinamide was more active than a control regimen against drug-susceptible pulmonary tuberculosis, researchers reported at the 2014 Conference on Retroviruses and Opportunistic Infections.

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