Healio

Low clinical value in repeat latent TB tests in patients taking biologics

TLANTA — Repeat, routine testing for latent tuberculosis infection among patients receiving biologics is both costly and of low clinical value, according to findings presented at the 2019 ACR/ARP Annual Meeting.

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Xpert Ultra assay identifies pediatric TB with high sensitivity

An updated version of the Xpert Mycobacterium tuberculosis and rifampin assay, known as Ultra, demonstrated high sensitivity in diagnosing pulmonary tuberculosis in children compared with traditional bacteriologic testing, according to research published in Pediatrics.

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BCG vaccine safe in children exposed to anti-TNF alpha in utero

WASHINGTON — Children exposed to anti-TNF alpha in utero do not have a higher risk for developing tuberculosis following a Bacillus Calmette-Guerin vaccination, according to research presented at Digestive Disease Week.

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Long-term Sirturo therapy safe, effective against MDR-TB

Data presented at ECCMID 2016 showed that a 24-week or longer regimen of Sirturo was well-tolerated and effective against multidrug-resistant tuberculosis.

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Latent TB prevalence in China may be overestimated

Researchers from the Chinese Academy of Medical Sciences and Peking Union Medical College in Beijing have found tuberculin skin testing may be overestimating the prevalence of latent tuberculosis in China.

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Alcohol intake, viral load, CD4 count linked to active TB in HIV patients

Alcohol consumption, high viral load and low CD4 cell count appeared to be independent risk factors for developing active tuberculosis in patients with HIV, according to a report published in Open Forum Infectious Diseases.

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Anemia of inflammation often resolved after TB treatment

Chemotherapy for tuberculosis resulted in significant reductions in anemia of inflammation, but had no effect on iron-deficiency anemia or multifactorial anemia, according to researchers from Cornell University.

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Acquired rifampicin resistance more likely in HIV-coinfected patients

Patients with HIV and tuberculosis were more likely to develop acquired rifampicin resistance when treated with a thrice-weekly tuberculosis treatment compared with patients not coinfected with HIV, according to researchers from the National Institute for Research in Tuberculosis in India.

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Rapid MDR-TB test improved clinical outcomes

A rapid molecular diagnostic test significantly reduced the time to treatment initiation in patients with multidrug-resistant tuberculosis, new data suggest.

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Treating MDR-TB increased risk of acquired resistance to second-line drugs

The treatment of multidrug-resistant tuberculosis significantly increases the risk of acquired resistance to second-line drugs and upgrading the condition to extensively drug-resistant tuberculosis, according to data from a new study.

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