Items tagged with Vaccines

Temperature-stable experimental TB vaccine enters clinical testing (post)

Vaccinations have begun in a Phase 1 human clinical trial testing a freeze-dried, temperature-stable formulation of an experimental tuberculosis (TB) vaccine candidate. The trial is being conducted at the Saint Louis University School of Medicine Center for Vaccine Development and will enroll as many as 48 healthy adult volunteers aged 18 to 55 years. The experimental vaccine, called ID93, was developed by scientists at the Infectious Disease Research Institute (IDRI) in Seattle. The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, is supporting the trial through a contract to IDRI.

Open access TB publications in The Lancet Global Health (post)

Alternative vaccination route protects against TB (post)

Rijswijk, 21 January - A different approach to vaccination could stop hypersensitive rhesus monkeys from developing tuberculosis (TB). Researchers from the Biomedical Primate Research Centre (BPRC) have demonstrated that administration of the existing BCG vaccine via the airways instead of the skin can protect against TB. As far as is known, this is the first time that the protection of rhesus monkeys against infection with TB - by means of a preventive vaccine - has been documented. Nature Medicine, a prominent scientific magazine, published the BPRC article about this study this week.

BCG vaccine scars tied to decline in infant mortality (post)

Scarring caused by bacillus Calmette-Guérin, or BCG, vaccine in both mothers and infants was associated with a significant decrease in infant mortality, according to findings from a randomized controlled trial published in the Journal of the Pediatric Infectious Diseases Society. The researchers wrote that the effect of the tuberculosis vaccine on mortality was not as strong when only the child had scarring.

Texas Biomed scientists developing new vaccine strategy for TB (post)

For years, scientists have been trying to come up with a better way to protect people against tuberculosis, the disease caused by infection with the Mycobacterium tuberculosis (Mtb) bacteria. Texas Biomedical Research Institute Professor Jordi Torrelles, Ph.D., says new hope is on the horizon after a recent experiment performed in mice showed great promise. The study was published in the journal Mucosal Immunology.

Tuberculosis vaccines: Rising opportunities (post)

A perspective published in PLOS Medicine reflects on the progress of the TB vaccine development.

Report of the High-level consultation on accelerating the development of the M72/AS01E TB vaccine candidate (post)

The High-level consultation on accelerating the development of the M72/AS01E tuberculosis vaccine candidate was convened by the World Health Organization on 5 April 2019.

ICMR launches third phase trial for adult TB vaccine (post)

The Indian Council of Medical Research (ICMR) on July 15, 2019 said it has launched the third-phase trials for an anti-Tuberculosis vaccine that could be administered to anybody aged six years and above. Current BCG vaccines is only for neonates.

Old vaccine brings new surprises (post)

New research about an old vaccine – one that has been in use for nearly 100 years – has not only shown how effective it is but also suggests it improves our immune response to a wider range of bacteria than originally intended.

Thermally-stable TB vaccine closer to reality thanks to microscopic silica cages (post)

Scientists working on a new tuberculosis (TB) vaccine have achieved a major step forward by showing that a promising TB antigen and a novel vaccine adjuvant can be protected from heat damage with a technique developed at the University of Bath.