Items tagged with Treatment

India: 1st in 50 years: Nod for new tuberculosis drug (post)

With cases of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant TB (XDR-TB) threatening the country, Bedaquiline the first anti-TB drug manufactured after Rifampicin (almost 50 years ago) has been approved for use in India. Bedaquiline is so far approved in the US, EU and other major countries. In a recent meeting, India’s apex committee on drugs recommended waiver of local clinical trials for the drug and suggested its use under the government’s run programme for TB.

Five more drugs get local clinical trial waiver for importing, marketing in India (post)

The Union Health Ministry accorded permission to five more drugs—chronic hepatitis C drug Sofosbuvir, prostrate cancer drug Enzalutamide, cutaneous T-cell lymphoma drug Vorinostat, pulmonary tuberculosis drug Bedaquiline tablets 100 mg and Haemophilia drug Rixubis—for importing and marketing in India without local clinical trial on Indian population.

Once weekly combination regimen effective for childhood tuberculosis (post)

MedicalResearch.com Interview with:
Dr. Stefan Goldberg MD
Medical Officer in CDC’s Division of Tuberculosis Elimination
Clinical Research Branch

Antiangiogenesis drugs could make major improvement in tuberculosis treatment (post)

Use of the same antiangiogenesis drugs that have improved treatment of some cancers could also help surmount persistent difficulties in treating tuberculosis (TB). In their PNAS Early Edition report, investigators from Massachusetts General Hospital (MGH) and the National Institute of Allergy and Infectious Disease (NIAID) show that blood vessels supplying pulmonary granulomas – dense masses of immune cells that surround pockets of the TB bacteria in the lungs of infected patients – have the same sort of structural and functional abnormalities seen in solid tumors and that treatment with the antiangiogenesis drug bevacizumab (Avastin) significantly improved delivery of a small-molecule drug surrogate within granulomas in an animal model. 

Good outcomes within the National Bedaquiline Clinical Access programme in South Africa (post)

The South African Bedaquiline Clinical Access Programme showed good interim outcomes in people with drug resistant tuberculosis (DR-TB), according to data presented at the 45th Union Conference on Lung Health.

Pharmacokinetics and safety of moxifloxacin in children (post)

Moxifloxacin concentrations were lower in children than adults according to pharmacokinetic (PK) data presented at the 45th Union World Conference on Lung Health. [1]

Problems giving current second line TB drugs to children (post)

Results from a survey presented at 45th Union World Conference on Lung Health reveal an urgent need for child appropriate formulations of second line TB drugs. [1]

Indian government backs SIRTURO® (bedaquiline) for treatment of multidrug-resistant tuberculosis (MDR-TB) (post)

29 January 2015 - New Delhi, India -- On January 14, 2015, The Drugs Controller General of India (DCGI) approved SIRTURO® (bedaquiline) for use in adults (>18 years) as part of combination therapy of pulmonary tuberculosis due to multidrug-resistant Mycobacterium tuberculosis (MTR-TB), when an effective treatment regimen cannot otherwise be provided.

New antibiotic to treat multidrug-resistant tuberculosis (MDR-TB) receives approval in Peru (post)

29 January 2015 -- Lima, Peru - Pulmonary multidrug-resistant tuberculosis (MDR-TB) causes the deaths of over 200,000 people globally each year. With an estimated 2,000 cases in 2013, Peru has the highest prevalence of MDR-TB in Latin America and the Caribbean and cases have significantly increased since 2009 . On December 13th 2014, Janssen, the pharmaceutical affiliate of Johnson & Johnson, received approval for SIRTURO® (bedaquiline) from the Peruvian health authorities.

Lamprene effectively treats MDR-TB (post)

Adding Lamprene to current tuberculosis therapy demonstrated higher treatment success than standard treatment alone in treating multidrug-resistant tuberculosis, researchers in China have found.

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