Texas Biomedical Research Institute

Texas Biomed researchers pinpoint why HIV patients are more likely to develop TB

Tuberculosis and HIV – two of the world’s deadliest infectious diseases – are far worse when they occur together. Now, Texas Biomedical Research Institute researchers have pinpointed an important mechanism at work in this troubling health problem. And, their discovery could lead to a new mode of treatment for people at risk. The results were published in the Journal of Clinical Investigation, a top-tier venue for critical advances in biomedical research.

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Lung lining fluid key to elderly susceptibility to TB infection

Old lungs are not as capable as young lungs of fighting off an infection of the bacteria that causes tuberculosis (TB), placing seniors at a greater risk of developing TB. The microbe that causes this infectious disease, Mycobacterium tuberculosis (Mtb), currently kills more people in the world than any other pathogen.

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Researchers develop faster, cheaper test for TB

Diagnosing tuberculosis might soon be cheaper and take less time thanks to a test developed by researchers at the Texas Biomedical Research Institute’s Population Health program.

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NIH funds creation of new lab model for TB/HIV research

San Antonio, Texas (June 26, 2019) – When people suffer from both HIV and TB, it creates “one of the biggest health problems in the world,” according to Texas Biomed Assistant Professor Smita Kulkarni, Ph.D. Now, the National Institutes of Health is funding a two-year study by Texas Biomed scientists developing a lab model that mimics the early stages of the co-infection of these two diseases.

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Texas Biomed scientists developing new vaccine strategy for TB

For years, scientists have been trying to come up with a better way to protect people against tuberculosis, the disease caused by infection with the Mycobacterium tuberculosis (Mtb) bacteria. Texas Biomedical Research Institute Professor Jordi Torrelles, Ph.D., says new hope is on the horizon after a recent experiment performed in mice showed great promise. The study was published in the journal Mucosal Immunology.

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New discovery could lead to ways to protect HIV patients from deadly TB

Director of the Southwest National Primate Research Center Professor Deepak Kaushal, Ph.D. says research he collaborated on is pinpointing a possible new avenue of protection for HIV/AIDS patients. The study, published this month in the journal Cell Reports helps scientists better understand how HIV promotes deadly cases of tuberculosis (TB).

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Repurposing promising cancer drugs may lead to a new approach to treating TB

Promising experimental cancer chemotherapy drugs may help knock out another life-threatening disease: tuberculosis (TB). A new study published by scientists at Texas Biomedical Research Institute in San Antonio pinpoints a mechanism in regulating cell death called apoptosis that is a potential new target for helping to control the bacterial infection (Mycobacterium tuberculosis or M.tb) that causes the lung disease TB. 

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Texas Biomed part of team receiving five-year, $4.4 million NIH grant for novel TB vaccine testing

San Antonio, Texas (August 21, 2017) – Tuberculosis (TB) is the leading cause of death due to infectious disease worldwide. Texas Biomedical Research Institute Associate Scientist Dr. Marie-Claire Gauduin has partnered with Dr. Chinnaswamy Jagannath, professor of pathology and laboratory medicine at McGovern Medical School at UTHealth in Houston to test a modified TB vaccine that, if effective, could prove more powerful and provide longer lasting immunity. Dr. Gauduin and Dr. Jagannath are principal investigators on this study.

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