Document

Use of interferon-gamma release assays in support of TB diagnosis

Author: European Center for Disease Prevention and Control
Recommended citation: European Center for Disease Prevention and Control . Use of interferon-gamma release assays in support of TB diagnosis . 2011. http://ecdc.europa.eu/en/publications/publications/1103_gui_igra.pdf.
Published: 2011

Description

This report outlines the evidence on IGRAs and their utilization in the diagnosis of latent and active tuberculosis. The document concludes that ‘IGRAs should not replace the standard diagnostic methods for diagnosing active TB.’ It also discusses some clinical circumstances that IGRAs could provide an additional value such as: patients with extrapulmonary TB, patients who test negative for acid-fast bacilli in sputum and/or negative for M. tuberculosis on culture, TB diagnosis in children, or in the differential diagnosis of infection with non-tuberculous mycobacteria.
Tags: Diagnostics