Items tagged with Vaccines
Vaccinations have begun in a Phase 1 human clinical trial testing a freeze-dried, temperature-stable formulation of an experimental tuberculosis (TB) vaccine candidate. The trial is being conducted at the Saint Louis University School of Medicine Center for Vaccine Development and will enroll as many as 48 healthy adult volunteers aged 18 to 55 years. The experimental vaccine, called ID93, was developed by scientists at the Infectious Disease Research Institute (IDRI) in Seattle. The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, is supporting the trial through a contract to IDRI.
Rijswijk, 21 January - A different approach to vaccination could stop hypersensitive rhesus monkeys from developing tuberculosis (TB). Researchers from the Biomedical Primate Research Centre (BPRC) have demonstrated that administration of the existing BCG vaccine via the airways instead of the skin can protect against TB. As far as is known, this is the first time that the protection of rhesus monkeys against infection with TB - by means of a preventive vaccine - has been documented. Nature Medicine, a prominent scientific magazine, published the BPRC article about this study this week.
Scarring caused by bacillus Calmette-Guérin, or BCG, vaccine in both mothers and infants was associated with a significant decrease in infant mortality, according to findings from a randomized controlled trial published in the Journal of the Pediatric Infectious Diseases Society. The researchers wrote that the effect of the tuberculosis vaccine on mortality was not as strong when only the child had scarring.
For years, scientists have been trying to come up with a better way to protect people against tuberculosis, the disease caused by infection with the Mycobacterium tuberculosis (Mtb) bacteria. Texas Biomedical Research Institute Professor Jordi Torrelles, Ph.D., says new hope is on the horizon after a recent experiment performed in mice showed great promise. The study was published in the journal Mucosal Immunology.
A perspective published in PLOS Medicine reflects on the progress of the TB vaccine development.
Report of the High-level consultation on accelerating the development of the M72/AS01E TB vaccine candidate (post)
The High-level consultation on accelerating the development of the M72/AS01E tuberculosis vaccine candidate was convened by the World Health Organization on 5 April 2019.
Novel vaccine trial design aims to answer key TB questions (post with simple image)
Prevention of infection study underway in South Africa.
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