Items tagged with HIV coinfection

Large increase in early ART among people with TB in Uganda clinics (post)

Numbers of HIV-positive people who started antiretroviral therapy (ART) during treatment for tuberculosis rose 4- to 5-fold from 2006 to 2012 at two Uganda HIV clinic, reflecting new data and evolving guidelines. But many HIV-positive people with higher CD4 counts still did not start ART if they have TB, despite World Health Organization advice.

Cotrimoxazole prophylaxis neither reduces TB risk nor complicates TB diagnosis in people with HIV (post)

Cotrimoxazole prophylaxis has no impact on incidence or detection of tuberculosis (TB) in people with HIV, a study published PLoS One shows. The prospective, observational study involved 2393 adult participants in Soweto, South Africa. All had a CD4 cell count below 350 cells/mm3. Participants taking cotrimoxazole prophylaxis actually had a higher risk of TB compared to participants not taking the treatment. But the authors believe this was due to residual confounding. Prophylaxis with the drug did not compromise TB diagnosis and had a protective effect in term of overall mortality.

Gates Foundation, SA link to combat HIV, TB, malaria (post)

The Bill and Melinda Gates Foundation has partnered with SA institutions to develop new medicines and vaccines for HIV, TB and malaria.

Union study provides findings on best rifabutin dosage for TB patients on antiretroviral therapy (post)

The results of a phase II pharmacokinetics study conducted by The Union and its partners in Vietnam were published today in the scientific journal PlosOne. The study assessed different doses of rifabutin in combination with protease inhibitor-based antiretroviral therapy (ART) for HIV-infected patients who are also infected with TB. 

Pulmonary TB in 17% of HIV+ Asian children, one third already on ART (post)

Almost 1 in 5 HIV-positive children in a 13-year Asian observational study had pulmonary tuberculosis. More than one third of pulmonary TB cases developed after antiretroviral therapy (ART) had begun.

IFRC and Global Fund target tuberculosis treatment for all in Niger (post)

Geneva – The International Federation of Red Cross and Red Crescent Societies (IFRC) and the Global Fund to Fight AIDS, Tuberculosis and Malaria have signed a grant agreement to fund universal treatment for tuberculosis (TB) in Niger, a country with one of the worst rates of TB in West Africa.

HIV associated with increased risk of MDR-TB (post)

HIV infection is associated with an increased risk of multi-drug-resistant tuberculosis (MDR-TB), results of a systematic review and meta-analysis published in PLOS ONE show. HIV increased the risk of MDR-TB by 24%. The analysis included 24 separate studies with a total patient population of 93,000. The investigators believe their findings have important implications for TB control programmes in terms of detection, appropriate treatment, infection control and follow-up.

Poor survival with XDR TB in South Africa, but ART improves survival (post)

Three quarters of South African patients with extensively drug-resistant (XDR) tuberculosis died within 5 years of treatment, according to results of a 107-patient analysis in three South African provinces. Among people with HIV infection, taking antiretroviral therapy (ART) was independently associated with survival.

Increased TB incidence In Zimbabwe associated with food insecurity, economic collapse (post)

Results of a study released by the University of Toronto Dalla Lana School of Public Health and published in PLOS ONE state that the “rise of tuberculosis (TB) in Zimbabwe during the socio-economic crisis of 2008-9 has been linked to widespread food shortage.” According to the University of Toronto’s press release, “‘This was the first study to detect the recent TB outbreak in Zimbabwe, and the first anywhere to suggest an association between rising TB incidence and national economic decline in the absence of armed conflict,’ said Michael Silverman, assistant professor at the Dalla Lana School of Public Health and senior author of the study. Although the same phenomenon may occur with other infectious diseases, the study focused on TB — one of the largest causes of morbidity and mortality in Zimbabwe, especially among people living with HIV…” (2/5).

India: HIV+ patient with TB kills himself (post)

The depressed 16-yr-old boy, who was admitted to the Sewri hospital, had told his mother that he had lost all hope of recovering.

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