Items tagged with Diagnostics

2014 Advanced Tuberculosis Diagnostic Research Course Presentations now available online (post)

Presentations from an intensive, high-level course on TB diagnostic research methods at McGill University in Montreal, held 7-11 July 2014, are now available online. Presentation topics include the TB diagnostics development pipeline, target product profiles, implementation research, guideline development, modeling, and cost-effectiveness.

Cepheid reports China installed base close to 1,000 GeneXpert® systems (post)

SUNNYVALE, Calif., July 29, 2014 /PRNewswire/ -- With the recent completion of a record shipment of 774 GeneXpert systems to a single country in one quarter, Cepheid (Nasdaq: CPHD) today applauded groundbreaking tuberculosis programs in China where more than a million new cases of tuberculosis (TB) are reported each year.  Combined with systems placed previously, the second quarter placements bring the cumulative total of GeneXpert systems in China to more than 970.  The purchase of almost 170,000 Xpert® MTB-RIF cartridges will support the initial roll out of the systems throughout the rest of 2014.

Operational lessons drawn from pilot implementation of Xpert MTB/Rif in Brazil (post)

In health services in areas with a high burden of tuberculosis, diagnosis can be especially difficult because it takes several weeks or months to obtain the results of mycobacterial culture, which is the gold standard test for the diagnosis of tuberculosis. In such settings, diagnosis is usually based on microscopic examination of at least two sputum smears, but because sputum smear microscopy has low sensitivity, patients are often started on antituberculous therapy based on clinical evidence, without bacteriological confirmation. This leads to the underreporting of tuberculosis cases, unnecessary exposure to therapy with potential toxicity, and delay in the correct diagnosis and treatment of patients. In Brazil, around 26% of new tuberculosis cases are not confirmed with any bacteriological test and culture is not performed in 73% of re-treatment cases.

Xpert use reduced wait for treatment, study shows, but health system, patient challenges remain barriers to full benefits (post)

The demand for, and the promise of, quick accurate tools to diagnose tuberculosis, and to discover resistance to basic TB treatments, are based on a simple and seemingly irrefutable premise. Such tools, it has been pointed out, make early and effective treatment possible, benefiting both patients and public with faster and more frequent cures, and lowering transmission.

Rapid MDR-TB test improved clinical outcomes (post)

A rapid molecular diagnostic test significantly reduced the time to treatment initiation in patients with multidrug-resistant tuberculosis, new data suggest.

Researchers develop new DNA sequencing method to diagnose tuberculosis (post)

Researchers working in the UK and The Gambia, have developed a new approach to the diagnosis of tuberculosis (TB) that relies on direct sequencing of DNA extracted from sputum (a technique called metagenomics) to detect and characterize the bacteria that cause TB without the need for time-consuming culture of bacteria in the laboratory.

Experts at LSTM use novel modelling approach to assess the effectiveness of new diagnostics for TB (post)

Experts at LSTM have used a novel modelling approach to project the effects of new diagnostic methods and algorithms for the diagnosis of tuberculosis (TB) recently endorsed by the World Health Organization (WHO), looking at the patient, health system and population perspective in Tanzania.

Boost in quest for TB breath test (post)

A simple breath test may one day show whether someone has a strain of tuberculosis that will respond to a frontline antibiotic, or a drug-resistant type, scientists said Tuesday (September 23).

Abbott introduces new molecular test to aid in the diagnosis of tuberculosis (post)

October 8, 2014 - Abbott announced today it received CE mark approval for a new molecular diagnostic test for detection of Mycobacterium tuberculosis (MTB), the bacteria that causes tuberculosis (TB), which continues to be a major global public health threat.

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