Items tagged with Diagnostics

Priorities for Bacteriology Services in Low-Income Countries (document)

This guide, known as the “Red Book” dispenses guidance to national officials responsible for reference laboratories on the principal responsibilities such as technical and organisational aspects of smear examination and drug-resistance surveillance.

Use of interferon-gamma release assays in support of TB diagnosis (document)

This report outlines the evidence on IGRAs and their utilization in the diagnosis of latent and active tuberculosis. The document concludes that ‘IGRAs should not replace the standard diagnostic methods for diagnosing active TB.’ It also discusses some clinical circumstances that IGRAs could provide an additional value such as: patients with extrapulmonary TB, patients who test negative for acid-fast bacilli in sputum and/or negative for M. tuberculosis on culture, TB diagnosis in children, or in the differential diagnosis of infection with non-tuberculous mycobacteria.

A Tuberculosis Guide for Specialist Physicians (document)

This document discusses the need for cooperation between tuberculosis control programmes and specialist physicians and the important role of specialist physicians have in an NTP. Each chapter covers critical topics in TB including: epidemiology, pathogenesis, diagnosis, treatment, re-treatment, drug resistance, control, and special populations (HIV, elderly).

Time of great change in TB drug development (post with simple image)

We are living in a time of great change and excitement in TB drug development. The last year has witnessed a number of epochal changes, including the approval and rollout of the most rapid test for TB ever discovered, the GeneXpert; the combination TB drug studies in the relapse mouse model of Eric Nuermberger and Jacques Grosset at Johns Hopkins with support from the TB Alliance; the progression of TMC207 into late phase II and of OPC67683 into phase III; and the first new regimen EBA study, NC-001 also from the Alliance.

TB CAB, TAG open letter to Cepheid (post with simple image)

Re: GeneXpert machine and Xpert MTB/RIF cartridge pricing, extended warranties and business in Russia and the People’s Republic of China

Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults (post with simple image)

A second systematic review of a diagnostic test for TB endorsed by WHO, has confirmed the accuracy of the test. Xpert® MTB/RIF is more accurate than smear microscopy for diagnosing TB and also accurate for detecting rifampicin resistance.

GeneXpert use still hobbled by high pricing, Treatment Action Group, TB Community Advisory Board say (post with simple image)

Letter to Cepheid cites continued cost of machines, Russia, China cartridge costs of five to six times negotiated price, and more.

Call for a patient-centered approach to TB diagnostics (post with simple image)

To prioritize an agenda for implementing TB diagnostics that centers upon the patient with TB symptoms and highlights patient well-being and cure.

Point-of-care diagnostics for tuberculosis elimination? (post with simple image)

The projected epidemiological effect of Xpert MTB/RIF might be overestimated, so this fascinating and promising new tool is unlikely to be the magic bullet that paves the way towards tuberculosis elimination.

Xpert TB test doesn’t reduce morbidity but it does have important advantages (post with simple image)

The need for a highly sensitive and specific affordable point-of-care TB test remains urgent.

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