Items tagged with Diagnostics
Sputum-based molecular assay accurately identifies culture-confirmed TB (post)
A sputum-based molecular testing strategy (GeneXpert MTB/RIF) was safe, feasible, easily adopted, and was associated with both clinical and economic benefits in guiding the discontinuation of respiratory isolation for patients undergoing evaluation for active tuberculosis (TB), according to findings from a prospective cohort study published in JAMA Internal Medicine.
India: TB among children can now be diagnosed in two hours (post)
New Delhi: It may prove to be a major shot in the arms of Health Ministry as the pilot project started to diagnose tuberculosis among the children of the age group up to 2 years has turned out to be a great success. With the help of the new technique, detection of TB among children can now be done in just two-hour, which was earlier not possible.
TB symptom screen less likely to detect active TB in people taking HIV treatment (post)
The four-symptom screen for active tuberculosis (TB) that is recommended for all people living with HIV in lower-income settings is less likely to detect active TB in people taking antiretroviral therapy (ART) and may be improved by the additional use of a chest x-ray, according to a systematic review and meta-analysis by the World Health Organization (WHO).
Study confirms poor ability of tests to predict active TB infection (post)
A prospective study examining the ability of tests to predict the development of active tuberculosis found a similarly low positive predictive value in high-burden settings of interferon- release assays, or IGRAs, and tuberculin skin tests, or TBTs, researchers reported in The Lancet Infectious Diseases. The negative predictive value of the tests was high in all settings.
WHO and FIND: Technical guide on sequencing (post)
The World Health Organization (WHO) and FIND released a technical guide on sequencing, The use of next-generation sequencing technologies for the detection of mutations associated with drug resistance in Mycobacterium tuberculosis complex: technical guide.
Outbreak of multidrug-resistant TB in South Africa undetected by standard tests (post)
Due to inadequate lab tests, an outbreak of multidrug-resistant tuberculosis (MDR-TB) in South Africa has remained undetected for no less than five years. An international team of microbiologists led by Dr Emmanuel André (KU Leuven) and his South African colleague Ndivhuho Makhado present their findings in Lancet Infectious Diseases.
Improved detection of drug-resistant TB using genetic and culture-based laboratory methods (post)
24 October 2018, New York - WHO and partners released a series of documents today to improve drug susceptibility testing for TB in laboratories worldwide.
GeneXpert can test stool samples to accurately diagnose TB in children (post)
THE HAGUE, Netherlands, October 25, 2018 – Drug susceptible and drug resistant forms of tuberculosis in children can be accurately diagnosed by using existing GeneXpert machines and cartridges to test stool samples for TB bacteria, researchers announced here. Not only can GeneXpert accurately diagnose TB and drug resistance in a fraction of the time it takes to diagnose TB using sputum, Petra de Haas of the KNCV Tuberculosis Foundation said, in a study conducted in Indonesia comparing the two samples more TB cases were detected using stool samples than sputum samples.
Machine learning identifies antibiotic resistance genes in TB-causing bacteria (post)
Researchers at the University of California San Diego have developed an approach that uses machine learning to identify and predict which genes make infectious bacteria resistant to antibiotics. The approach was tested on strains of Mycobacterium tuberculosis—the bacteria that cause tuberculosis (TB) in humans. It identified 33 known and 24 new antibiotic resistance genes in these bacteria.
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