Brief news reports on Tuberculosis

Childhood TB: Act before it is too late

A significant proportion - about 15% to 20% - of all tuberculosis (TB) occurs in children in India, where paediatric TB is a serious, but under-recognized and neglected public health problem.

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Cambodia's tuberculosis prevalence rate declines sharply in last decade: new survey

PHNOM PENH, Feb. 8 (Xinhua) -- The tuberculosis prevalence rate in Cambodia has seen a 36 percent decline in the last decade, according to a new survey released on Wednesday.

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US gives Vietnam help in testing TB

The United States has given Vietnam new equipment to help speed up the diagnosis of a drug resistant strain of tuberculosis.

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Should efavirenz be dosed higher when coadministered with rifampin?

On January 6, 2012, the FDA announced that the package insert for efavirenz has been updated to include a new dosing recommendation for HIV-infected patients with tuberculosis (TB): When efavirenz is coadministered with rifampin in patients weighing ≥50 kg, it should be dosed at 800 mg once daily instead of the usual 600 mg daily. The evidence cited to support this recommendation is from drug–drug interaction trials and a pharmacokinetic modeling study. These studies suggest that coadministration reduces systemic exposure to efavirenz when that drug is given at 600 mg daily, but not when it is given at 800 mg daily; at the higher dose, systemic exposure is comparable to that achieved when efavirenz is dosed at 600 mg daily without rifampin.

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WHO asks India to conduct nationwide study on MDR-TB

Multi drug resistant tuberculosis (MDR-TB) is spreading far and wide across the globe. The latest World Health Organisation (WHO) analysis published on Saturday said cases of MDR-TB had now been reported from 80 countries, in some instances in almost 30% of all newly diagnosed cases.

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Deathly friendship of bacteria and virus: TB-HIV co-infection

The clinical course and opportunistic infections of HIV vary from patient to patient and country to country. In India TB is a major opportunistic infection in people living with HIV (PLHIV), with over 35% PLHIV co-infected with TB-HIV. There is an estimated 3.52% faster progression to death if a PLHIV suffers from TB also. Even today in India, two deaths occur every three minutes from TB. Major challenges to control TB in India include poor primary health-care infrastructure especially in rural areas; unregulated private health care leading to widespread irrational use of first-line and second-line anti-TB drugs, poverty, social stigma and lack of political will.

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Back from the dead: the story of Elizabeth

We find her busy making chapattis with the help of her daughter and nephew. She does not look anything like the woman we met when we visited her six months ago (see One foot in the grave, July 2011). The only thing that has not changed about her is her bright and welcoming smile. She is Elizabeth Wambui Nthumbi, a 32-year-old from Kenya’s Kawangware slum who barely a year ago had one foot in the grave and was wondering why death was not knocking in her door despite the fact that she was ready for it.

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Inaccurate TB blood tests commonplace in many TB high-burden countries

Although recent press attention has highlighted the problematic use of TB serological tests by medical providers in India, a new paper in The European Respiratory Journal (Widespread use of serological tests for tuberculosis: data from 22 high-burden countries) demonstrates that the use of these tests is much wider spread.

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'Goldilocks' gene could determine best treatment for tuberculosis patients

Tuberculosis patients may receive treatments in the future according to what version they have of a single 'Goldilocks' gene, says an international research team from Oxford University, King's College London, Vietnam and the USA.

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Ghana: Boost for TB case detection

The Ministries of Health, Finance and Economic Planning, and the Royal Netherlands, have signed a budgetary grant of 7.5 million EUR to accelerate tuberculosis case detection in Ghana.

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