Johns Hopkins Medicine

Nearly 1 in 5 Tibetan refugee schoolchildren has TB infection, Johns Hopkins study finds

Zero TB in Tibetan Kids outreach program aims to eliminate the disease in an entire population in India.

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PET scans to optimize TB meningitis treatments and personalize care, study finds

Although relatively rare in the United States, and accounting for fewer than 5 percent of tuberculosis cases worldwide, TB of the brain--or tuberculosis meningitis (TBM)--is often deadly, always hard to treat, and a particular threat to young children. It may leave survivors with lifelong brain damage. Now, researchers at Johns Hopkins Medicine report they have used PET scans, a rabbit model and a specially tagged version of the TB drug rifampin to advance physicians' understanding of this disease by showing precisely how little rifampin ever reaches the sites of TB infection in the brain.

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Computer model predicts potential impact of short-course therapy against MDR-TB

Johns Hopkins researchers have developed a computer simulation that helps predict under which circumstances a new short-course treatment regimen for drug-resistant tuberculosis could substantially reduce the global incidence and spread of the disease.

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Researchers advance treatment of TB by targeting new enzyme

Researchers at Johns Hopkins report they have laid the foundation to develop novel antibiotics that work against incurable, antibiotic-resistant bacteria like tuberculosis by targeting an enzyme essential to the production and integrity of bacterial cell walls.

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Mouse studies show experimental TB treatment may do more harm than good

Johns Hopkins researchers report evidence from mouse studies that a “repurposed” drug that would be expected to improve the immune system response of tuberculosis patients may be increasing resistance to the antibiotic drugs these patients must also take.

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Proactively treating HIV patients at risk for tuberculosis with multidrug TB therapy doesn’t save more lives

March 17, 2016 - In what investigators say is a surprise finding, results of a new study appear to strongly affirm the effectiveness of prescribing the anti-tuberculosis drug isoniazid alone — in place of the standard four-drug regimen — to prevent TB and reduce death in people with advanced HIV/AIDS infections. Those with HIV and AIDS are highly susceptible to TB.

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Scientists take steps to make weak TB drugs strong again

January 19, 2016 - Biophysicists have discovered why the bacteria that cause tuberculosis (TB) are naturally somewhat resistant to antibiotics known as fluoroquinolones. Their findings, based on mapping the detailed three-dimensional structure of the drugs interacting with an essential enzyme in the TB germ, also reveal why some TB drugs are more potent than others and suggest how drug developers can make fluoroquinolones more efficacious against mutations that make the lung disease drug resistant.

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Preventive antibiotics for tuberculosis reduce deaths among people with HIV disease

Study shows isoniazid therapy should be considered for millions of HIV-infected people globally.

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