Mark Mascolini

WHO TB diagnostics may prevent more deaths than standard of care

World Health Organization (WHO)-recommended strategies for diagnosing tuberculosis would prevent more deaths than the standard approach now used in most parts of sub-Saharan Africa, according to results of a cost-effectiveness analysis of people starting antiretroviral therapy (ART) by the US Centers for Disease Control and Prevention (CDC). One of the WHO strategies cost less than the current approach.

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TB incidence lower with ART in rich countries, but not at age 50+

Tuberculosis incidence was 44% lower in HIV-positive people in high-income countries who started antiretroviral therapy (ART) than in those who did not. But the protective effect of ART did not extend to people older than 50 or with a CD4 count below 50 cells/μL.

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Mortality similar with or without TB in HIV+ of Dar es Salaam on ART

HIV-positive adults with active tuberculosis when starting antiretroviral therapy (ART) in Dar es Salaam, Tanzania had a similar death rate as people without active TB 48 weeks after treatment began.

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Twin testing for TB/HIV would boost HIV diagnoses in India

Testing all clinic patients for HIV when they get tested for tuberculosis in India’s Mandya district would increase the HIV case-finding rate 51%, according to results of a 1668-person study.

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Low-cost urine test to diagnose TB in South Africans with HIV

Determine TB-LAM, a urine antigen test for pumonary tuberculosis screening, proved reasonably sensitive in HIV-positive people with low CD4 counts, according to results of a 500-patient study at an antiretroviral clinic in Gugulethu township, South Africa. Sensitivity improved when Determine TB-LAM was combined with sputum smear microscopy.

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