German Center for Infection Research

Tuberculosis: Inhibiting host cell death with immunotherapy

Tuberculosis treatment still entails the intake several antibiotics over a period of many months and is torturous for many patients. The pathogen’s increasing multidrug resistance additionally complicates this lengthy treatment, and side effects frequently lead to a discontinuation of treatment and high mortality rates. Developing alternative treatment approaches is therefore of critical importance. DZIF scientists from the University Hospital Cologne are working on an immunotherapy that supports antibiotic treatment. In their current study, they were able to identify a new target protein in human immune cells, which can inhibit the bacteria’s destructive effects.

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