American Society for Microbiology

TB drugs work better with vitamin C

Washington, DC – January 3, 2018 – Studies in mice and in tissue cultures suggest that giving vitamin C with tuberculosis drugs could reduce the unusually long time it takes these drugs to eradicate this pathogen. The research is published in Antimicrobial Agents and Chemotherapy, a journal of the American Society for Microbiology.

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New diagnostics tool, the Xpert Ultra assay, improves detection of TB

Washington, DC – August 29, 2017 – Researchers have demonstrated a new, improved version of the Xpert  MTB/RIF assay, a test for Rifampicin-resistance (RIF-R). The Xpert “Ultra” assay overcomes the shortcomings of the current Xpert assay to significantly improve tuberculosis detection, especially in patients with pauci-bacillary disease. The new Xpert Ultra assay also provides a more reliable detection of Rifampicin resistance (RIF-R). The research is published this week in mBio, an open-access journal of the American Society for Microbiology.

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Cleverly designed TB vaccine shows promise in mice

Washington, DC - January 13, 2017 - A clever new tuberculosis vaccine has shown promise in trials in mice. If it succeeds, it will be the first new TB vaccine in a century. With the rise of multidrug resistant tuberculosis, the difficulty of curing the disease, and the large annual death toll, a successful vaccine could be a huge benefit to public health--especially in low- and middle income countries. The research is published January 13th in Applied and Environmental Microbiology, a journal of the American Society for Microbiology.

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Reducing drug dosage, and hearing loss in TB patients without reducing efficacy

Aminoglycosides, recommended by the World Health Organization to treat multidrug resistant tuberculosis, cause hearing loss and kidney damage in a dose dependent manner. Now, by reducing the dose in a carefully calculated fashion, Dutch clinician researchers have been able to greatly reduce the numbers of patients suffering hearing loss, without compromising effectiveness against tuberculosis. The research was published in Antimicrobial Agents and Chemotherapy, a journal of the American Society for Microbiology.

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Scientists identify new route of TB transmission

Washington, DC - May 10, 2016 - Scientists have discovered a new species of bacteria, Mycobacterium mungi, that causes tuberculosis (TB) and is transmitted through the skin and nose of banded mongoose in Northern Botswana. The findings, published May 10 in the journal mBio, have radically changed scientists understanding of how tuberculosis can be transmitted.

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