Point-of-care diagnostics for HIV and TB: Landscape, pipeline, and unmet needs

Early diagnosis and rapid initiation of treatment remains a key strategy to control both HIV and TB. However, HIV and TB control programs have had completely contrasting successes, especially with the development and deployment of point-of-care diagnostics.

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India's Ministry of Health dismisses claims of Totally Drug-Resistant TB

In a January 17 statement, India's Ministry of Health and Family Welfare "dismissed reports that a form of incurable tuberculosis [TB] has arrived in the country," saying "that a team of doctors sent by the ministry found that seven of the patients are responding to treatment" and the cases would be classified and managed as extremely drug-resistant TB (XDR-TB), Nature News Blog reports (Jayaraman, 1/19).

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TB and a gene mutation that causes lung cancer linked

Tuberculosis (TB) has been suspected to increase a person's risk of lung cancer because the pulmonary inflammation and fibrosis can induce genetic damage. However, direct evidence of specific genetic changes and the disease have not been extensively reported.

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University of Cape Town and McGill University to run high-level courses on TB diagnostic research methods

An intensive high-level courses on TB diagnosis research will take place at the University of Cape Town from 6-9 March 2012 and repeated at McGill University from 9-13 July 2012.

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Totally Drug Resistant TB strain turns up in patients in India

Doctors at the Hinduja National Hospital and Research Centre in Mumbai, India, are reporting on a strain of tuberculosis (TB) emerging among patients that is resistant to all first- and second-line drugs used to treat the bacterial infection. At least twelve patients have been identified so far.  The doctors do not present evidence that the resistant strain is passing from human to human, and mostly focus on how TDR can develop in TB infected individuals due to poor treatment management.

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Childhood TB: Forgotten but not gone

Tuberculosis (TB) in children is often a neglected issue, in terms of prevention, diagnosis, treatment, and monitoring prevalence. The best numbers we have are from the World Health Organization (WHO), according to Mandy Slutsker of ACTION, an international partnership of global health advocates. The WHO reported in 2009 that every year more than 1 million children get infected and about 176,000 die as a result. However, since most cases go unreported, the numbers are likely much higher, she said.

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We're upgrading this weekend!

We're upgrading TB Online this weekend. The site might behave erratically and be up and down quite a bit over the next 72 hours. Apologies in advance. It should all be working properly again by Monday morning.

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CDC issues new TB treatment guidelines

They're aimed at shortening, simplifying the regimen used to prevent active disease. The new guidelines apply only to the United States.

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STOP TB response to activist letter

Here is the STOP TB response to this letter by activists on its future governance. 

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Africa must do for self in tuberculosis fight

A World Health Organization (WHO) report revealed that significant progress toward eradicating tuberculosis (TB) globally was achieved in the last two decades. TB is a common and often deadly infectious disease spread through the air, when people who have the disease cough or sneeze. Usually it attacks the lungs but can also affect other parts of the body. TB usually starts as an asymptomatic, latent infection that becomes an active disease, which untreated, kills more than half of its victims.

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